Messi, who has struggled for form in recent weeks due to a niggling injury, looked on a mission to grab the winner and after twice coming close he completed his treble to put Barca ahead in the 85th minute, reacting quickly to a poor Sevilla clearance to dink the ball over goalkeeper Tomas Vaclik.
Celta Vigo thrashed Barcelona 4-1 on Wednesday with Iago Aspas hitting a double.
Barcelona capitalised on two disastrous own goals by A S Roma to thrash the Italian side 4-1 at the Nou Camp on Wednesday and take a huge step towards reaching the Champions League semi-finals for the first time in three years.
Sweden beat Italy 1-0 to gain the upperhand after their World Cup playoff first leg on a chilly night, while a young England side held Germany goalless and Belgium drew 3-3 with Mexico despite Romelu Lukaku's double but France eased to a 2-0 victory against Wales.
Leaders Barcelona and Real Madrid were held to draws while Sevilla made up ground on the top two and Alaves slipped after a promising start. Here are five talking points from the weekend's La Liga action.
World champions Germany drew 1-1 with Spain in a high tempo friendly on Friday as they launched their preparations for a title defence in Russia while their opponents had striker Diego Costa making his long-awaited comeback as a substitute.
Germany's Lukas Podolski capped his international swansong with a sensational goal to give the world champions a 1-0 victory over England in a friendly on Wednesday.
Luis Suarez scored four goals and Lionel Messi grabbed a hat-trick as Barcelona all but wrapped up their King's Cup semi-final by crushing Valencia 7-0 in the first leg at the Nou Camp on Wednesday.
A mesmeric Lionel Messi helped Barcelona to come from behind and beat Sevilla 2-1 in a thrilling encounter on Sunday as the champions kept the pressure on La Liga leaders Real Madrid, who saw off Leganes 3-0 thanks to a double from Gareth Bale.
Real Madrid and Atletico each slipped 10 points behind La Liga leaders Barcelona after an intense Madrid derby finished goalless and the Catalans picked up an 11th victory in 12 games by winning 3-0 at Leganes.
The pain of missing out on a first domestic league crown for 29 years will be eased by the knowledge that European glory could be on the horizon for Liverpool
Germany coach Joachim Loew has named four talented youngsters, including three uncapped players, in his preliminary 27-man squad for Euro 2016.
Argentina's Lionel Messi and Carlos Tevez, English third tier player David Hall and U.S. women's international Carli Lloyd were among players included on the shortlist for FIFA's goal of the year award on Friday.
A round-up of Wednesday's night's UEFA Chmpions League matches.
If Arsenal are to have any chance of overturning a 2-0 deficit against Barcelona in the Champions League next month they must be sharper in front of goal, says manager Arsene Wenger. They worked hard to keep the world's most fearsome attacking trio of Lionel Messi, Luis Suarez and Neymar relatively quiet until the 71st minute of Tuesday's last 16, first-leg tie but by then they had spurned two excellent chances to take the lead. Alex Oxlade-Chamberlain was the culprit in the first half, anxiously shooting straight at Barcelona goalkeeper Marc-Andre ter Stegen, then Frenchman Olivier Giroud failed to convert the kind of close-range header he regularly dispatches. They are the sort of opportunitites that must be taken in the return at the Nou Camp on March 16 when Arsenal face what many pundits think is 'mission impossible' after Messi showed how it should be done with two late goals at The Emirates. The Argentine's first strike followed a clinical counter-attack and his second from the penalty spot in the 83rd came after he was brought down by substitute Mathieu Flamini. "We had an unbelievable chance in the first half and the way we finished our chances is a problem," Wenger told reporters after his side's demoralising defeat.
Cameroonian teenager Wilfrid Kaptoum scored a late equaliser to give Barcelona a 1-1 draw at Valencia that wrapped up an 8-1 aggregate success in their King's Cup semi-final on Wednesday.
Holders Barcelona cruised into the King's Cup quarter-finals when a side missing several regulars beat city rivals Espanyol 2-0, with Munir El Haddadi netting both goals in a thumping 6-1 aggregate success on Wednesday.
When Barcelona host local rivals Espanyol on Saturday hoping to edge closer to the La Liga title, many may be haunted by Raul Tamudo's 89th minute equaliser which wrecked their title bid in 2006/07.
La Liga leaders Barcelona handed Real Madrid more hope in the title race as they drew 0-0 at Athletic Bilbao on Sunday, only avoiding defeat thanks to some outstanding saves by Marc-Andre ter Stegen.
IMAGES from the La Liga matches played on Tuesday
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Real Madrid talisman Cristiano Ronaldo and Barcelona striker Luis Suarez took centre stage on Saturday in bailing their teams out with late strikes to silence their critics following slow starts to the season.
Barcelona goalkeeper Victor Valdes is likely to be out of action until the end of the year after suffering a calf strain during Spain's surprise defeat by South Africa on Tuesday, the club said in a statement on their website.
Lionel Messi, Luis Suarez and Neymar combined to devastating effect as Barcelona swatted Celtic aside 7-0 at the Nou Camp to lay down a marker in Champions League Group C on Tuesday.
Bundesliga leaders Borussia Dortmund suffered a shock first defeat of the season, letting in two late goals to slump to a 2-0 loss at Borussia Moenchengladbach on Saturday.
Two late goals in two minutes from Sergi Roberto and Luis Suarez gave European champions Barcelona a dramatic 2-1 win over Bayer Leverkusen in the Champions League on Tuesday.
Two goals from Arda Turan and one from Lionel Messi gave Barcelona a 3-0 win over Sevilla in the Spanish Super Cup second leg on Wednesday to seal a 5-0 aggregate victory.
Cristiano Ronaldo and Gareth Bale both scored as Real Madrid staged a remarkable late comeback from two goals down to win 3-2 at Villarreal and stay top of La Liga.
IMAGES from the UEFA Champions League quarter-final 2nd leg matches played on Tuesday
An insatiable Lionel Messi scored for the eighth game in a row in all competitions as La Liga champions Barcelona saw off a gutsy Girona side 2-0 to go five points clear at the top of the standings.
Lionel Messi struck a spectacular free kick, scored another goal and set up two more in a 4-1 victory for Barcelona over nine-man city rivals Espanyol in the first leg of their King's Cup last-16 clash on Wednesday.
Holders Barcelona crashed out of the Champions League after being stifled by a brilliantly well-organised Atletico Madrid.
It was a dramatic night at the Champions League as Barcelona's Anssumane Fati -- 17 years and 40 days old - became the youngest to net a goal in the competition. Last season's semi-finalists, Ajax were eliminated by Valencia while Napoli's coach Ancelotti was shown the door despite the team's progress. Here are Images from the Champions League matches played on Tuesday
Barcelona completed one of the most extraordinary comebacks in European football history to knock Paris St Germain out of the Champions League on Wednesday with a 6-1 victory that rewrote the record books.
Images from the UEFA Champions League quarter-final first leg matches played on Wednesday
Barcelona forward Ousmane Dembele scored twice and produced a mesmerising display to fire his side to a 5-1 win over Villarreal on Wednesday which stretched the champions' unbeaten run this season to 36 games with two remaining.
Cristiano Ronaldo shrugged off the boos of his own supporters to fire Real Madrid to a 3-0 win over Real Sociedad on Sunday.
Champions Barcelona suffered their second defeat in three matches in La Liga on Saturday, with Michael Krohn-Dehli scoring and setting up another goal in a 2-1 victory for Sevilla.
Two goals from Thomas Mueller and one from substitute Mario Goetze helped Bayern Munich kick off their Champions League campaign with an impressive 3-0 victory over Olympiakos.
Germany eased into the Confederations Cup semi-finals with a 3-1 win over Cameroon on Sunday as the VAR system was again thrust into the spotlight when the on-field official needed two reviews of an incident to reach the right verdict.