The 32-year-old, who captained the Dutch to third place at the 2014 World Cup in Brazil, has been overlooked by coach Danny Blind, who is not convinced about his form with Fenerbahce.
Luuk de Jong scored a hat-trick and Memphis Depay netted the winner in the third minute of stoppage time as PSV Eindhoven beat Feyenoord 4-3 in a thrilling clash that put them four points clear on Wednesday.
PSV Eindhoven played for more than 20 minutes with 10 men but held on for a goalless draw at home to Atletico Madrid in the first leg of their Champions League last-16 tie on Wednesday.
Lionel Messi scored a record eighth Champions League hat-trick as Barcelona kick-started their campaign with a 4-0 home win over PSV Eindhoven, although they had defender Samuel Umtiti sent off late in the second half on Tuesday.
Atletico Madrid celebrated like they had won the trophy after reaching the Champions League quarter-finals by edging past PSV Eindhoven 8-7 on penalties on Tuesday following 210 goalless minutes in their last-16 tie.
Portugal's Cristiano Ronaldo celebrated his Madeira homecoming with an early strike but Sweden wrecked the party by hitting back from two down to win 3-2.
A summary of Tuesday night's matches in the UEFA champions League.
The Netherlands failed to reach the European Championship for the first time since 1984 as they lost 3-2 at home to the 10-man Czech Republic in their final qualifier on Tuesday to miss out on Euro 2016.
Cristiano Ronaldo scored two stunning goals and took his international tally to 70 as he led Portugal to an emphatic 3-0 win over Hungary in a World Cup qualifier on Saturday.
Atletico Madrid sealed top spot in Champions League Group D after second half goals from Frenchmen Kevin Gameiro and Antoine Griezmann but Napoli were held to a 0-0 Champions League draw at home by Dynamo Kiev.
A round-up of all the international friendlies played on Tuesday
Photos from the Champions League matches played on Wednesday.
Switzerland struck twice in quick succession to stun Euro 2016 champions Portugal 2-0 in a World Cup qualifier on Tuesday and hand them a first competitive defeat in two years under coach Fernando Santos.