It is not yet clear how Liverpool will split their squad and whether Klopp will be present at both games.
The Reds have won 28 of their 31 Premier League matches this season.
Steven Gerrard says he has been dreading the moment he must wave goodbye to his adoring Anfield fans .
Real Madrid produced a stunning comeback from two goals down to earn a devastating 5-2 victory at Liverpool
He acknowledged that police had been caught off-guard by local delinquents who turned up to cause trouble at the match. But defending the security protocols in place, the minister said France had only had three months to prepare after the venue was moved from Russia.
'They were better than us for some spells and we know what awaits us over there' Valverde pointed to his team's sensational exit from last year's competition to AS Roma after a 4-1 cushion from the first leg and said they would be taking nothing for granted in Tuesday's return game at Anfield.
The much-anticipated clash between Liverpool and ManchesterCity at Anfield on Saturday looks like a knockout to determine who can challenge Chelsea for the Premier League title.
Gerrard will wave goodbye to the Liverpool fans in his final home match against Crystal Palace on Saturday.