Atletico Madrid earned a 1-1 draw away to Girona in a chaotic and entertaining Copa del Rey last 16 first-leg match on Wednesday, leaving the tie finely balanced.
Real's victory at the Santiago Bernabeu means they are poised to knock Atletico out of the competition for the fourth successive year.
Atletico coach Simeone defends VAR for making football fairer
Lionel Messi scored his maiden goal for Paris St Germain in Tuesday's 2-0 Champions League victory against Manchester City.
Atletico Madrid striker Mario Mandzukic's early goal secured a 1-0 win over Real Madrid and a 2-1 aggregate success to clinch the Spanish Super Cup and gain some revenge for last season's Champions League final defeat.
Barcelona were pitted against Italian champions Juventus in the Champions League quarter-final draw made on Friday to set up a repeat of the 2015 final which the Spanish side won 3-1.
Atletico Madrid will have centre backs Diego Godin and Stefan Savic available again for Tuesday's Champions League quarter-final first leg at Barcelona.
La Liga leaders Real Madrid dropped points at home for only the second time this season.
Atletico Madrid stayed firmly on course for a surprise La Liga title triumph when Raul Garcia's header secured a 1-0 win for the leaders at home to seventh-placed Villarreal on Saturday.
Arsenal are not only hoping to win a first European trophy since 1994, but know their hopes of qualifying for next year's Champions League depend on winning the Europa League in the French city of Lyon next month.
A round-up of Saturday's action in LaLiga, Ligue 1 and Serie A.
Their limp performance does not inspire confidence ahead of the visit of the all-powerful Serie A leaders and familiar foe Cristiano Ronaldo.
A first half Tiago header set up Atletico Madrid's 2-0 victory over Espanyol as they seek to get back on track following a stuttering start to the La Liga season.
Real Madrid barged their way back into the Spanish La Liga title race with a 3-1 victory over Atletico Madrid in a feisty derby at the Wanda Metropolitano on Saturday.
IMAGES from the UEFA Champions League quarter-final played between Atletico Madrid and Leipzig on Thursday.
News of all that's transpired on and off the football field
In other ties, Serie A champions Juventus face Europa League winners Atletico Madrid and Barcelona take on Olympique Lyonnais.
Real Madrid will be without forward pair Cristiano Ronaldo and Gareth Bale, midfielder Toni Kroos and defender Pepe for Tuesday's UEFA Super Cup encounter with Sevilla in Trondheim, Norway.
When Griezmann fired Atletico to victory over Olympique de Marseille in the Europa League final in May it was widely viewed as his last stand for Diego Simeone's side before a move to Barca but they successfully convinced the Frenchman to stay.
The France striker was fouled by Leicester's Marc Albrighton on the edge of the box and referee Jonas Eriksson deemed the action to have continued into the penalty area.
Mandzukic signing adds to the Serie A champs' big haul of strikers as Paul Pogba is targetted by Barca and PSG among other clubs
Two years on from their defeat by Real Madrid in the Champions League final, Atletico Madrid are back on the same stage against the same rival - wiser and determined not to be haunted by the memories of Lisbon.
Bayern Munich's outgoing coach Pep Guardiola has failed to make an impact at the club despite keeping the Bavarian giants as the dominant force in Germany, the club's former forward Ivica Olic said on Thursday.
Lionel Messi scored one penalty and missed another as Barcelona beat Real Valladolid 1-0 on Saturday to open up a seven-point lead at the top of La Liga.
'You realise the fear when Barcelona could get knocked out. It would hurt UEFA a lot. I don't know what they have to do for someone to send one of them off'
It was Messi's 30th goal in 39 competitive games against Atletico
The 28-year-old did not reveal where he would be playing next but widespread reports in the Spanish media said he would be joining Barcelona.
Atletico Madrid are close to tying up a deal for Spain forward Fernando Torres to return to his boyhood club on loan from Chelsea.
Argentina's two iconic players may be contrasting characters but they shared many traits
Images from La Liga matches played on Saturday.
Former Barcelona great Michael Laudrup lambasted the Brazil international for "provoking" the opposition in Saturday's 5-1 win at Leganes and Neymar's flamboyant style will be scrutinised again on Wednesday when Barcelona host Atletico.
Juventus supporters coach Massimiliano Allegri has often been in his element when he is apparently on the back foot.
La Liga leaders Barcelona beat Real Madrid 1-0 to all but knock their rivals out of the title race on Saturday, while second-placed Atletico Madrid stayed seven points behind the Catalans with a 2-0 win at Real Sociedad on Sunday.
'I haven't always expressed myself well. I said I would like to play with Neymar and Mbappe, but that doesn't mean I want to go to PSG'
Argentina, still reeling from the shock resignations of captain Lionel Messi and coach Gerardo Martino, have chosen Edgardo Bauza as their new coach, the Argentine FA said on Monday.
Images from Wednesday's action in the Champions League.
News of all that's transpired on and off the football field
Striker Mariano's header was glanced onto the crossbar by Sociedad's Andoni Gorosabel while the loose ball fell to Marco Asensio, whose shot was deflected wide for a corner from which Raphael Varane header hit the top of the bar.
Barcelona have emerged as favourites to be crowned champions after one defeat in their last 22 Liga games.
Images from matches played across top football leagues in Europe.
