Djokovic struggled to find his range early in the contest as Spaniard Davidovich Fokina raced to lead
Surprise package Davidovich Fokina, who knocked out top-ranked Novak Djokovic and Indian Wells champion Taylor Fritz in the earlier rounds at Monaco, drew first blood by breaking Tsitsipas to take a 2-1 lead in the opening set.
Playing his first match since injuring his knee at Indian Wells last month, Nadal showed no signs of rust as he raced into a 5-0 lead in the first set on Court Rainier III.
World number one Novak Djokovic's French Open preparations were dealt with a blow as he suffered a 6-3, 4-6, 6-2 defeat by Russian Daniil Medvedev in the Monte Carlo Masters quarter-finals on Friday.
hampion Rafael Nadal and top-ranked Novak Djokovic turned in impressive displays to reach the Monte Carlo Masters quarter-finals on Thursday. Nadal, chasing a record-extending 12th Monte Carlo title, broke Grigor Dimitrov's serve on four occasions to defeat the Bulgarian 6-4 6-1.