Marek Hamsik gave hosts Napoli an early lead 10 minutes into the game before Paolo Cannavaro and a Davide Astori own goal made it 3-0 as they galloped towards a fifth straight league win.
Napoli shot to the top of Serie A with a controversial 3-0 win at 10-man Inter Milan on Saturday as Claudio Ranieri suffered his first defeat in charge and was sent off at halftime.
Serie A leaders AC Milan slipped up for the second straight game in a 1-1 draw at Genoa on Sunday which opened the door for Napoli to cut the gap at the top to three points.
Lazio survived a storming Napoli fight back, including a missed penalty, as they won 4-2 on Sunday to finish third in Serie A and qualify for the Champions League playoff round after both teams finished with 10 men.
Two goals in three devastating second-half minutes helped Napoli reach the Italian Cup final on Wednesday with a 3-0 win over AS Roma in the second leg of their semi-final in Naples, to clinch the tie 5-3 on aggregate.
Two goals in three minutes from Napoli's Goran Pandev were not enough to secure victory as his side threw away a two-goal lead to draw 3-3 at home to Udinese in an end-to-end Serie A thriller on Saturday.
Gonzalo Higuain netted twice, the first a superb individual effort, to give Napoli a 4-2 win at Lazio while Fiorentina beat Hellas Verona 4-3 in a Serie A scoring spree on Monday.
New Liverpool boss Juergen Klopp made it three wins from his last three matches with a 1-0 success at Rubin Kazan in Russia that left them second in Group B, two points behind Swiss club Sion on Thursday.