Charlton Athletic moved into the fourth spot in the Premier League standings with a 3-1 victory over London rivals Fulham.
European champions Liverpool were beaten 0-2 by Fulham in the English Premier League.
The Dutch striker scored twice in a 3-2 triumph at Fulham.
The defending champions notched up their fifth Premier League victory of the season with a 2-0 win over Sunderland as their main title rivals both dropped points.
The English clubs were paired in the FA Cup semi-final draw on Friday
Arsenal moved on to 77 points, 11 behind newly crowned champions Chelsea but four clear of Manchester United.
England striker Peter Crouch netted twice as the six-times winners won the FA Cup quarter-final 7-0.
Liverpool ended their 85-year Manchester United jinx when a first-half Peter Crouch header gave them a 1-0 win in the FA Cup fifth round.
The Blues suffered a 4-2 battering at London rivals Charlton Athletic.
The defeat was especially costly for Claudio Ranieri's expensively assembled team who began the day in joint second place with title rivals Arsenal.
The champions beat Aston Villa 2-1 while Manchester United went down 1-2 at home to Blackburn Rovers in the Premier League.
A round-up of the weekend's action in the major European leagues.
Liverpool moved into the top five of the English Premier League with a 2-1 victory at relegation-threatened Norwich City.
Chelsea midfielder Scott Parker has broken a bone in his foot and will be out of action until next year, the Premier League club said on their website on Monday.
Former England defender Chris Powell has completed his free transfer from Charlton Athletic to English second division club West Ham, officials said on Friday.
Charlton's 1-0 victory takes them up three places to seventh in the table, while Blackburn remain 15th
The Dutch striker scored twice in a 2-0 victory over Charlton Athletic in the English premier league.
Manchester United were celebrating their eighth premier league title in 11 seasons on Sunday after Arsenal lost 3-2 at home to Leeds.
They beat Charlton Athletic 2-0 in the premier league.
"We have 11 games to go and we have tricky away games," the Arsenal manager said.
Big-spending Chelsea snatched a late and barely deserved 1-0 win at Manchester City to take second place, edging ahead of champions United on goal difference.
The Charlton Athletic midfielder joined Chelsea in a 10-million-pound deal.
A 1-1 draw at Charlton Athletic sent Arsenal back to the top of the premier league.