The result also means second-placed Real Sociedad can reclaim top spot if they beat Eibar on Sunday.
Juventus's hopes of reaching the Champions League last eight suffered a blow when the two-times European Cup winners slumped to a 1-0 defeat in their last-16 first leg at Olympique Lyonnais on Wednesday. Manchester City finally produced a Champions League performance worthy of their status as one of European football's elite clubs by beating Real Madrid 2-1 away in Wednesday's last-16 first leg after pulling off a stunning late fightback.
A round-up of Wednesday's league stage matches in the UEFA Champions League.
La Liga leaders Barcelona moved 10 points clear with a 4-1 win at Real Betis on Sunday after second place Atletico Madrid slipped up at Athletic Bilbao on Saturday in a 2-0 defeat.
Real Madrid president Florentino Perez has hinted the world's richest club by income could buy Monaco's Colombia striker Radamel Falcao next year.
Real Madrid have endured a miserable season since Zinedine Zidane left in May, first sacking Julen Lopetegui and then Santiago Solari.
Gareth Bale proved his worth to Real Madrid by delivering the Champions League trophy with a sensational two goals after coming off the bench in the 3-1 win
Real Madrid's reliance on their talisman Cristiano Ronaldo was more evident than ever on Tuesday as the Spanish and European champions meekly lost 1-0 at Espanyol in La Liga.
Pepe has blasted the Liga club's fans as "unenthusiastic", contrasting the hushed atmosphere of the Santiago Bernabeu stadium with the cauldron of noise he is now exposed to with Turkish champions Besiktas.
'They probably need to refresh the team a bit more, to be very honest. They have kept the majority of the same team for the last couple of years'
Real Madrid opened a two-point lead over Villarreal at the top of La Liga when Cristiano Ronaldo set a club scoring record in a 3-0 stroll at home to Levante on Saturday.
Cristiano Ronaldo was sent off as leaders Real Madrid beat Cordoba 2-1 in La Liga on Saturday thanks to late Gareth Bale penalty.
Barcelona blew the La Liga title race wide open when Lionel Messi scored a hat-trick in a 4-3 comeback win for the champions at 10-man Real Madrid in an action-packed 'Clasico' on Sunday.
Karim Benzema came off the bench to score 13 minutes from time and ruin any chance of a dream result for resilient Ludogorets as holders Real Madrid carved out a patchy 2-1 win in Wednesday's Champions League Group B match.
Real Madrid talisman Cristiano Ronaldo faces an emotional reunion with boyhood club Sporting Lisbon when his side begin the defence of their Champions League crown on Wednesday. Ronaldo, who scored the decisive penalty in the shootout win over Atletico Madrid in last season's final, returned to club football following an injury layoff when he scored in the 5-2 thrashing of Osasuna on Saturday.
Real Madrid coach Zinedine Zidane has opened the door to out-of-favour midfielder James Rodriguez leaving the club by admitting the player's lack of appearances could become a problem.
In other European football action Real Madrid were left frustrated after a goalless draw against Athletic Bilbao in their La Liga match on Sunday.
Real Madrid left back Marcelo admitted he was fortunate not to concede a penalty during their 2-2 draw with Bayern Munich at the Bernabeu, a let-off that helped the holders reach the Champions League final 4-3 on aggregate on Tuesday.
Cristiano Ronaldo continued his rich vein of form by scoring twice in Real Madrid's 2-1 home win over struggling Sporting Gijon on Saturday, although the La Liga leaders got a lucky break when the visitors squandered a second-half penalty.
Wolfsburg shock Real Madrid 2-0 to crown big European night.
Cristiano Ronaldo is eager to return to action as he prepares for his first start of the season when Real Madrid begin their Champions League defence on Wednesday against APOEL Nicosia, coach Zinedine Zidane said on Tuesday.
Champions Barcelona moved five points clear at the top of La Liga with a 2-1 win at Getafe, while Real Madrid fell to a 2-0 defeat by Real Sociedad.
The Portuguese forward, who also scored a treble in the quarter-final against Bayern Munich at the Santiago Bernabeu, and five goals across that tie, is revelling in the central striker's role he has adopted this season.
Cristiano Ronaldo kept up his rich La Liga scoring form as Real Madrid beat Villarreal 2-0 on Saturday to move up to fourth.
Here, Reuters Sport highlights five reasons why last season's double winners have collapsed.
Karius's manager Juergen Klopp said the keeper will be backed by the club.
Cristiano Ronaldo may have played his last game for Real Madrid after winning a fourth Champions League crown with the Spanish side in a 3-1 victory over Liverpool on Saturday, saying he would soon make an announcement on his future.
Real Madrid's teenage Brazilian duo Vinicius Junior and Rodrygo Goes sent them top of La Liga as both scored in a 2-0 win over Osasuna on Wednesday.
Brazilian Douglas Costa was in fine form as Bayern Munich beat Real Madrid 1-0 in a pre-season tournament.
The Belgian forward came off the bench to make his Real debut in Saturday's 3-2 win over Levante, having had his start to life at the club hit by a thigh injury the day before the La Liga season began.
Images from Tuesday night's UEFA Champions League group stage matches.
Portugal international Goncalo Guedes fired Valencia into the lead in the 35th minute with a thumping shot from inside the area which was too powerful for Madrid goalkeeper Keylor Navas.
Real Madrid trimmed Barcelona's lead at the top of La Liga to one point when they recovered from conceding an early goal to secure a stirring 3-1 comeback win in the 'Clasico' on Saturday.
Real Madrid survived an early Atletico Madrid onslaught to reach the Champions League final 4-2 on aggregate on Wednesday and set up a mouth-watering clash against Juventus.
Lionel Messi came off the bench to preserve Barcelona's unbeaten run in La Liga with a sensational late equaliser in a thrilling 2-2 draw at Sevilla on Saturday as the runaway leaders came back from two goals down in the space of a minute.
Meanwhile, Real Mallorca made a dream return to La Liga with a 2-1 victory over Eibar at the Estadi Son Moix on Saturday, less than two months after sealing back-to-back promotions to rejoin Spain's soccer elite.
Real Madrid have moved to broaden their options in attack by agreeing to sign Mexico striker Javier Hernandez on loan from Manchester United for the 2014-15 season.
Barcelona drew 1-1 at Valencia after Real Madrid lost 1-0 away to Alaves, allowing Sevilla to go top of La Liga with a 2-1 home win over Celta Vigo on Sunday. Here are five talking points from the weekend's La Liga action.
Real Madrid coach Zinedine Zidane is confident the team's results will not suffer from a one-year transfer ban imposed by FIFA for breaking rules regarding the signing of under-age foreign players.
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