'How could we have gone from a position of strength in the international community to virtual isolation,' asks Karl F Inderfurth, former US assistant secretary of state for South Asian affairs.
The resolution failed to be adopted on Thursday as it could not garner two-thirds support in the General Assembly.
The 15-member body strongly condemned North Korea's ballistic missile launches.
India was among the 11 countries that abstained from voting on the resolution in the UN Economic and Social Council.
The announcement of McMaster's ouster, who the White House said had a "good working relationship" with Trump, is the latest in a string of high-profile White House departures since President Trump took office in January 2017.
'Unlike Trump, who has an isolationist approach, Bolton would like to roam around the world, trampling upon any sign of dissent,' says Ambassador T P Sreenivasan.
'There seem to be no reason why Assad should have launched such an attack when he was gaining acceptability,' says Brigadier S K Chatterji (retd).
India along with China, Egypt, Iran, Iraq, Jordan, Kuwait, Oman, Pakistan, Qatar, Saudi Arabia and UAE voted against equal rights for gay staffers in UN