An emotional appearance against his old club by David Beckham, who missed the 2001 fixture, will not now happen as the former England captain's loan deal with Spurs looks ever-more likely to be more of an extended training session.
Scholes has an outside chance of featuring as he recovers from a groin problem that has sidelined him since November but Giggs is likely to play.
Also back should be Wayne Rooney and Nemanja Vidic, the latter bringing some much-needed solidity to what has looked a slightly shaky central defence in recent weeks.
Rooney scored his first club goal in open play since March 2010 when the 24-year-old England striker broke his nine-month drought on New Years' Day but picked up an ankle injury and missed the next two games.
Spurs will be hoping this season's formlines are a better indicator than the last 10 years.
They have lost at home only once, to Wigan Athletic, while United have drawn seven and won only two of their away games.
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