Saeed Ajmal captured four wickets on Thursday as Pakistan's spinners combined to reduce West Indies to 209 for nine at the close of the opening day of the first Test.
Ajmal's victims included opener Lendl Simmons, who top-scored with 49 after retiring hurt on 41, and the obdurate Shivnarine Chanderpaul who made 27.
Mohammad Hafeez and Abdur Rehman bagged two wickets each while left-arm paceman Wahab Riaz got the other one as the home side struggled to bat through the day on a pitch offering plenty of assistance to Pakistan's three spinners.
After winning the toss and electing to bat first, the home side batted patiently in the first session to overcome the early departure of Devon Smith for 13 in the sixth over and reach lunch on 66-1.
But Pakistan picked up another two wickets in the middle session then six more after tea to finish in a commanding position. Five of the nine wickets that fell were leg-before-wicket, including three to Ajmal.
Medium-pacer Wahab Riaz trapped Darren Bravo for 25 with an in-swinger that hit him low on the front pad then struck Simmons on his left knee when he was on 41.
Simmons survived a loud appeal but the impact left him writhing in pain and he hobbled off retired hurt.
He returned after the fall of the seventh wicket, adding eight more runs before falling agonizingly one short of his maiden test half-century.
West Indies 1st innings
D.Smith b Mohammad Hafeez 13
L.Simmons lbw b Saeed Ajmal 49
D.Bravo lbw b Wahab Riaz 25
R.Sarwan c Mohammad Salman b Abdur Rehman 23
S.Chanderpaul b Saeed Ajmal 27
B.Nash lbw b Saeed Ajmal 5
C.Baugh lbw b Saeed Ajmal 4
D.Sammy c Umar Akmal b Abdur Rehman 12
K.Roach not out 16
R.Rampaul lbw b Mohammad Hafeez 14
D.Bishoo not out 10
Extras (b-1 lb-7 w-1 nb-2) 11
Total (for nine wickets; 90 overs) 209
Fall of wickets: 1-15, 2-71, 3-127, 4-136, 5-142, 6-159, 7-162, 8-175, 9-198
Bowling: Umar Gul 13-0-40-0, Mohammad Hafeez 13-5-22-2, Abdur Rehman 26-9-46-2, Saeed Ajmal 29-12-63-4, Wahab Riaz 9-1-30-1.