She went down to 98th ranked Russian Vasilisa Bardina in the first round of the Bank of the West Classic.
Sania Mirza lost in the first round of her doubles match on Wednesday.
Top seeds Sania Mirza and Martina Hingis defeated Czech pair of Andrea Hlavackova and Lucie Hradecka in straight sets to virtually seal a women's doubles semi-final spot in the WTA Tennis Finals in Singapore.
The 19-year old Indian and Ana Ivanovic of Serbia beat Italy's Maria Elena Camerin and Tathiana Garbin at the Nasdaq 100 Open.
Newly-wed tennis star Sania Mirza said she will try to remain injury-free and her target will be to win medals in the Commonwealth and Asian Games later this year.
Top seed Anna Chakvetadze defeated India's Sania Mirza 6-3, 6-2 to win her first Stanford classic title.
'I gave what I had and I played my best. Winning and losing is all part of the game,' the Indian tennis ace said.
Leander Paes, who teamed with Martin Damm for his seventh Grand Slam triumph on Saturday, moved into the top 10 of the doubles rankings.
Top seed Sania Mirza quelled a late challenge from American wildcard Laura Granville to enter the quarter-finals of the US $75,000 ITF Vancuover Open on Thursday.
Indian tennis ace Sania Mirza and her Swiss partner Martina Hingis equalled the record for the longest women's doubles winning streak on Wednesday by advancing to the WTA Sydney International semi-finals with a straight set triumph.
Sania Mirza and Liezel Huber went down 6-2, 7-5 against Anna-Lena Groenefeld and Meghann Shaughnessy.
It pays to be a teenage sensation. Sania Mirza's irresistible glamour and popularity seems to have become a problem as another stalker tried to barge into her posh Hyderabad residence, seeking marital bliss with her.
The Indian ace and Yung-Jan Chan of Taipei were beaten in straight sets by Agnieszka and Urszula Radwanska of Poland in the final of the Istanbul Cup.
The Indian ace made a shocking exit from the Rogers Cup, losing to Italian qualifier Alberta Brianti.
Indian tennis ace Sania Mirza received a setback in her efforts to regain her form after revealing that her career-threatening wrist injury had returned.
The Indo-US pair beat the French-Venezuelan combination of Camille Pin and Milagros Sequera for a place in the final of the US $145,000 Tier IV Morocco Open.
The third seeds beat the Chinese-Uzbek pair of Meng Yuan and Varvara Lepchenko in the quarter-finals of the Cincinnati Open.
Sania Mirza continued to slide down the ranking ladder as the Indian is now placed at number 182, a loss of 41 places, in the latest WTA list issued on Monday.
Sania Mirza was leading 6-1, 2-0 when Alexandra Stevenson retired with a right shoulder strain.
Sania Mirza and Marta Domachowska beat Natalie Grandin and Milagros Sequera 6-4, 6-3 in the first round in Cincinnati
They beat Fernando Verdasco and Anabel Medina Garrigues in the first round of the mixed doubles at Wimbledon.
The Indian ace beat Flavia Pennetta 6-2, 7-6(5) at the Open Gaz de France in Paris
The Indian ace was called in to speak about 'Influencing Public Policy -The Role of the Celebrity'
The third seeded Indian ace got the better of Hana Sromova in a second round match.
According to sources, Sania's mother Naseema had rung up AITA Life President and ITF Vice President Anil Khanna on Thursday morning asking him to look into the reports that accuses Venus Williams to taking drugs at the Rio Games.
Upbeat after winning the Australian Open mixed doubles crown in the company of Sania Mirza, tennis ace Mahesh Bhupathi declared that he would continue teaming with the Hyderabadi ace in subsequent Grand Slam tournaments this year.
India's Sania Mirza and her partner Cara Black of Zimbabwe could not make it to the US Open women's doubles finals after going down in straight sets to Swiss-Italian pair of Martina Hingis and Flavia Pennetta at the Flushing Meadows.
The top seeded pair of Sania Mirza and Yaroslava Shvedova stormed into the doubles semi-finals in the US $220,000 Citi Open, beating Lindsay Lee-Waters and Megan Moulton-Levy in straight sets, at College Park, United States, on Friday. The Indo-Kazakh pair won 6-3, 6-4.
"It's great that Sourav came here and watched the match," said Sania.
The second seeded Indo-Russian pair needed just over an hour to get the better of the Argentine team of Gisela Dulko and Paola Suof 6-2, 6-3.
Sania Mirza and Elena Vesnina recovered from a second-set lapse against Timea Bacsinszky and Alberta Brianti to advance to the doubles quarter-finals of the Indian Wells WTA Premier event.
Sania Mirza and Francesca Schiavone's were handed a straight-set defeat by Spanirad Arantxa Parra Santonja and Edina Gallovits of Romania at the doubles event of the USD 220,000 Hobart International WTA tournament on Wednesday.
Sania Mirza, playing her first competitive match since a long injury lay-off, along with her Italian partner Francesca Schiavone reached the doubles quarter-finals of the USD 220,000 WTA Hobart International tournament on Monday.
They beat the American pair of Angela Haynes and Neha Uberoi in the first round of the women's doubles at the US Open.\n
The Indian ace won the first set but was outplayed in the next two by Francesca Schiavone in the second round of the US Open.
India's Sania Mirza overcame a fighting Meng Yuan in a three-setter to earn a shot at singles title of the US$ 50,000 ITF Challenger event in Lexington, United States. The second seed Indian beat sixth seed Chinese 6-1, 4-6, 6-4 in the semi-final of the hard court event.
John Farrington said the line call when Maria Sharapova was three breakpoints down on the serve changed the game away from Sania Mirza.