Modest Udinese, whose coach Francesco Guidolin's target this season is to avoid relegation, went top of Serie A on Sunday with a 2-1 win over Chievo while AC Milan were held 2-2 at Bologna.
Juventus slumped to another surprise defeat on Wednesday when the champions lost 1-0 at Sassuolo while AS Roma reclaimed top spot in Serie A with a 3-1 home victory over Udinese.
Arsenal enjoyed a 3-0 win in Azerbaijan against Qarabag in the Europa League on Thursday and AC Milan beat Greece's Olympiakos Piraeus 3-1 but Sevilla suffered a shock defeat by Russians Krasnodar.
Genoa blew away Serie A leaders Juventus on Sunday, scoring three times in an astonishing first half hour on the way to a pulsating 3-1 win.
Two goals in three minutes from Napoli's Goran Pandev were not enough to secure victory as his side threw away a two-goal lead to draw 3-3 at home to Udinese in an end-to-end Serie A thriller on Saturday.
Lazio squandered a two-goal lead against Inter Milan as they drew 2-2 at the San Siro on Sunday and wasted a golden chance to take sole possession of third spot in Serie A.
Francesco Totti made an instant impact on his return from a buttock injury when he scored one goal and helped set up another in AS Roma's 3-2 Serie A win over Udinese on Monday.