The former European champions face the prospect of elimination from the Champions League should they lose to Villarreal.
Wayne Rooney can single-handedly shape the fortunes of his team, the Argentine legend said
Champions Chelsea were held to a 1-1 draw by Aston Villa, Liverpool lost 2-0 at Bolton Wanderers and Arsenal rallied to beat Charlton Athletic 2-1 in Saturday's Premier League matches.
The Manchester United defender will not travel to the United States for the two-match tour.
Second-half goals from Wayne Rooney and John O'Shea gave them a 2-1 victory and second place in the EPL table.
Leaders Chelsea got back to winning ways with a 3-0 defeat of Newcastle United while Manchester United beat Charlton Athletic 3-1
European champions Liverpool were beaten 0-2 by Fulham in the English Premier League.
The defending champions notched up their fifth Premier League victory of the season with a 2-0 win over Sunderland as their main title rivals both dropped points.
The English clubs were paired in the FA Cup semi-final draw on Friday
England striker Peter Crouch netted twice as the six-times winners won the FA Cup quarter-final 7-0.
Manchester City's hopes of an unprecedented quadruple were in tatters on Sunday after holders Wigan Athletic repeated their FA Cup heroics with a stunning 2-1 victory in their quarter-final at the Etihad Stadium.
Liverpool ended their 85-year Manchester United jinx when a first-half Peter Crouch header gave them a 1-0 win in the FA Cup fifth round.
Striker Zlatan Ibrahimovic has leapt to the defence of club mate Wayne Rooney, saying the Manchester United captain is a "perfect" player who does not get enough respect in England.
Arsenal moved on to 77 points, 11 behind newly crowned champions Chelsea but four clear of Manchester United.
Charlton Athletic moved into the fourth spot in the Premier League standings with a 3-1 victory over London rivals Fulham.
The clash gives Portugal the chance to avenge their 1966 World Cup semi-final defeat in England.
The champions beat Aston Villa 2-1 while Manchester United went down 1-2 at home to Blackburn Rovers in the Premier League.
England striker Wayne Rooney has signed a four-year contract extension with Premier League champions Manchester United that will keep their prize asset at the club until June 2019.
A round-up of the weekend's action in the major European leagues.
The Blues suffered a 4-2 battering at London rivals Charlton Athletic.
The defeat was especially costly for Claudio Ranieri's expensively assembled team who began the day in joint second place with title rivals Arsenal.
Liverpool moved into the top five of the English Premier League with a 2-1 victory at relegation-threatened Norwich City.
The English Premier League champions won 1-0 at Newcastle United through a superbly struck volley by skipper Patrick Vieira.
Chelsea midfielder Scott Parker has broken a bone in his foot and will be out of action until next year, the Premier League club said on their website on Monday.
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