Spurs sacked Mauricio Pochettino on Tuesday before entrusting Mourinho with the task of reviving their fortunes.
Jose Mourinho's job could be on the line when Chelsea host Porto in the Champions League on Wednesday and Alex Ferguson has urged the Londoners not to jettison their manager even if the result goes against them.
Following is a match by match look at the English Premier League's weekend fixtures:
Chelsea manager Jose Mourinho has denied that the club's success is purely down to the financial muscle of owner Roman Abramovich.
After the Champions League semi-final exit and Premier League loss to Manchester United, Jose Mourinho's is hoping to at least win the FA Cup.
Tuchel has agreed an 18-month contract with the option of another year, the west London club announced.
Frank Lampard scored Chelsea's winner in a 1-0 pre-season victory over Feyenoord.
Chelsea coach Jose Mourinho believes striker Didier Drogba holds the key to their Champions League semi-final against Liverpool at Anfield.
The two sides will be meeting for the 14th time since Jose Mourinho and Rafael Benitez arrived in English football in 2004 and there is little they do not know about each other.
Chelsea's Dutch winger Arjen Robben needs an operation on his knee and could be out for the rest of the season.
Chelsea have re-signed midfielder Nemanja Matic from Benfica, three years after selling him to the Portuguese side, the Premier League club said on Wednesday.
Champions Chelsea and rivals Arsenal will be at full strength for Sunday's Premier League showcase game at Stamford Bridge.
A stunning free kick from Willian seven minutes from time gave Chelsea a nervy and hard-fought 2-1 UEFA Champions League Group G win over Dynamo Kiev on Wednesday to lift some of the gloom surrounding Stamford Bridge.
The Chelsea captain will miss Sunday's League Cup final against Arsenal after damaging his ankle.
Spain forward Fernando Torres believes that under new Chelsea coach Jose Mourinho he will be able to rediscover the form that made him one of the world's most feared strikers.
Manchester City's eight point advantage after 11 games is leading to talk of the Premier League title race being over in November, but as Manchester United manager Jose Mourinho noted - English football has a habit of throwing up surprises.
Manager Jose Mourinho says Chelsea's rivals will need to improve next season to have any chance of beating the English champions.
Andriy Shevchenko's 88th-minute strike helped AC Milan beat Chelsea 3-2 in the Champions World Series.
Chelsea retained the Premier League title when they crushed second-placed Manchester United 3-0 at Stamford Bridge on Saturday.
Two goals from Wayne Rooney gave Manchester United a 2-1 win at Tottenham Hotspur and denied Chelsea the chance to be crowned Premier League champions again on Monday.
Chelsea captain John Terry said he and his team mates are ready to plead the manager's case with the club hierarchy.
The EPL champions, Jose Mourinho and Ashley Cole were found guilty of breaking contract rules by the governing body.
Chelsea almost stole the points at the death but Argentine Hernan Crespo wasted two good chances while defender Ricardo Carvalho headed over.
Real Madrid president is targeting seven high-profile coaches for the Spanish club
Chelsea manager Jose Mourinho has much to ponder as he prepares his side for Saturday's local derby against Fulham at Stamford Bridge.
Jose Mourinho said Father Christmas must be a Chelsea fan after his side grabbed a last-gasp 3-2 win at Wigan Athletic on Saturday.
The duo are young young, articulate, and have shown themselves to be shrewd tacticians and expert motivators in leading two comparatively modest teams to the final
In Europe, Chelsea enjoy none of Liverpool's reputation, earned with five European Cup finals and four triumphs.
"If I leave Porto, I can't guarantee it will be England but if the alternative is Italy then England will be my choice," said Porto coach Jose Mourinho.
