The company had sacked former chief executive officer Phaneesh Murthy in May this year over an undisclosed relationship with a subordinate.
Pratt, who joined the firm in 2004, has left the company to start his own entrepreneurial venture.
India's second largest software services firm, Infosys on Thursday saw the exit of its global head of strategic sales, marketing and alliances Prasad Thrikutam.
TCS, Infosys do well but Wipro & HCL disappoint analysts; however, outlook for FY17 bullish in general.
He takes over from Ashutosh Vaidya, who will move into a full-time position as head of Global Delivery for Dell Services.