Australia vice-captain David Warner has a fractured left index finger, the team announced, on Sunday, and has been ruled out for rest of the series.
Warner will return home to nurse the injury ahead of the upcoming tour of Sri Lanka.
Opening batsman Warner suffered the injury while fielding during Saturday's victory over South Africa in the triangular one-day series in St Kitts.
"We will assess the situation over the coming days to see if the injury requires a surgical option but should that not be the case then David is likely to be available to return to play in somewhere between two and six weeks," team doctor Geoffrey Verrall said in a statement.
The final of the triangular contest, which also includes the host West Indies, will be played on June 26, which seems to rule Warner out for the rest of the series.
The injury comes as the left-hander is in some of the best form of his career.
Warner was named man of the match on Saturday after completing his first ODI century outside Australia, a knock of 109 off 120 balls at the appropriately-named Warner Park.
Just two weeks ago he captained Sunrisers Hyderabad to victory in the final of the Indian Premier League.
Warner is looking at the positives of his enforced absence after a busy stretch of cricket.
"It's obviously disappointing to be sidelined given the form I've been in (but this) will give me the chance to freshen up and spend quality time with my family after an intense period of action."
"He's in the form of his life and batting beautifully, so it's obviously going to be a big loss for us," said captain Steve Smith.
"But I'm sure whoever's going to step into that position is going to do a terrific job and hopefully we can continue the success we've had so far in the series.
"The most important thing is that he's right for the Test series (against Sri Lanka). I think the medical staff and Davey are confident he'll be fine for that first Test match."
Australia lead the triangular series with two victories from three games.
They next meet West Indies in St Kitts on Monday.