Group G leaders APOEL, the other surprise package, defend their unbeaten record away to Europa League and Portuguese champions Porto, who need to bounce back from their 3-1 defeat to Zenit St Petersburg in the previous round.
Other groups have been more predictable, especially Group H where AC Milan and Barcelona, with four points each, can take another step towards qualifying by winning at home to BATE Borisov and Viktoria Plzen respectively.
The two Eastern European sides have one point apiece.
Group E leaders Chelsea can also extend their dominance with a home win over bottom side Genk as can Group D leaders Real Madrid who host Olympique Lyon, the team they knocked out last season.
Also in Group D, four-times European champions Ajax Amsterdam visit Croatian champions Dinamo Zagreb with both hoping for their first win.
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