India's Sania Mirza and her partner Ivan Dodig were knocked out by Barbora Krejcikova and Marin Draganja in the mixed doubles at the 2016 US Open.
The Indo-Romanian pair defeated the Croat-Finnish combination of Marin Draganja and Henri Kontinen 5-7, 7-6(5), 10-6 to enter the Round of 32.
India's top singles player Somdev Devvarman was on Saturday drawn to a play a qualifier while wild cards Yuki Bhambri and Jeeven Nedunchehziyan will have to fight it out with top-100 players in their first rounds at the Aircel Chennai Open.