Defending champion Sloane Stephens was sent packing from the Miami Open on Sunday after a 6-3, 6-2 loss to Germany's Tatjana Maria in the third round.
Stephens, the 2017 US Open champion and world No. 6, had no answer to Florida-based Maria's slices, chips and lobs and suffered a second consecutive early exit after losing her first match in Indian Wells to Swiss qualifier Stefanie Vogele.
Earlier on Sunday, second seed Simona Halep fought back from a set down to defeat Polona Hercog while Venus Williams reached the next round with a straight sets win over Daria Kasatkina.
Maria, ranked 62nd in the world, celebrated prematurely on her third match point with a lob shot that was called out, but won on the next one when Stephens sent a backhand long.
"I could not be happier right now," the 31-year-old said. "I think I played at home, because I live here. It was helping me a lot.
"My game is pretty special, so I knew that tonight I had a chance. I played two times against Sloane, so I knew what to expect."
Halep had nothing but praise for Hercog, who has a world ranking of 93rd, after dropping the first set and being pushed all the way in the second by the Slovenian.
The Romanian dominated the tiebreak to turn the match around and eventually triumphed 5-7, 7-6(1), 6-2.
"It was not easy at all," Halep said. "I think the level was very, very high. She played unbelievable. If she keeps playing like this, she can be top 20 easy."
Halep grabbed the match by the scruff of the neck by winning five consecutive points in the second set tiebreak and after lucky loser Hercog pulled within 3-2 in the concluding set, Halep won the next three games to seal the match.
"I think in the end she got tired a little bit, then I was stepping a little bit forward to be more aggressive," Halep said.
"She didn't miss. So it was really difficult. It was a very, very high standard."
World number three Halep avoided becoming the third major player to exit the women's draw in two days after world number one Naomi Osaka was stunned by Taiwan's Hsieh Su-wei and Serena William withdrew with a knee injury.
She next faces three-time champion Venus Williams in the fourth round after the American won 6-3, 6-1 against Russian 14th seed Kasatkina, who failed to hold serve once
The seven-time Grand Slam champion broke Kasatkina eight times, losing just one game after trailing 3-2 in the opener.
"I think in a lot of the matches we played before, she was just on top of her game, couldn't miss," the former world number one said.
"I think today I was just able to control the points. Got a few more errors.
"I'm always at my best when I'm playing aggressive."
The Russian did not save a single break point and lost every service game.
"I didn't realise that until after the match looking at the stats," said Williams, who was broken four times. "I've never had a match before like that in my life."
In other matches, Latvian 11th seed Anastasija Sevastova lost 1-6, 6-2, 6-3 to Kazakh Yulia Putintseva, while 25th-seeded American Danielle Collins went down 7-5, 6-1 to China's Wang Yafan.
Djokovic beats Delbonis, stays on track for seventh Miami title
World number one Novak Djokovic staved off a spirited challenge from Federico Delbonis for a 7-5, 4-6, 6-1 win in the third round at the Miami Open on Sunday.
Like Roger Federer the previous day, top seed Djokovic found it tough going against an unseeded opponent before prevailing in two hours in the Florida twilight.
Eighty-third ranked Delbonis, a left-hander with perhaps the highest ball toss in the game, took it to Djokovic in the second set but could not maintain his form in the final set.
The result improved Djokovic's impressive record against Argentine players.
According to the ATP Tour, only Juan Martin del Potro has beaten Djokovic, who is 36-3 against Argentines since 2007.
Next up for the Serbian will be Spanish 22nd seed Roberto Bautista Agut, who prevailed 6-4, 6-4 over Italian 15th seed Fabio Fognini.
Earlier, defending champion John Isner unleashed 16 aces in a 7-5, 7-6(6) victory over determined Spaniard Albert Ramos-Vinolas.
Ramos-Vinolas broke Isner to start the match but the American saved the next four break points he faced to advance.
"I did a lot of things well today," Isner said. "I played a good first set, even though I didn't start it off well. In the second, it wasn't quite as clean.
"I'll talk to my coach and try to iron things out. But I'm into the round of 16 of a big tournament and I'm happy."
The seventh seed will face Britain's 19th-seeded Kyle Edmund in the fourth round.
Edmund beat Canadian 12th seed Milos Raonic 6-4, 6-4.
Isner has practised with Edmund in Miami and they have split two meetings.