Portuguese striker Hugo Almeida scored twice as Besiktas produced the biggest win of the night, a 5-1 demolition of Maccabi Tel Aviv.
Stoke City, playing in European competition for the first time since 1972, were denied a win at Dynamo Kiev when Ognjen Vukojevic scored in stoppage time for the 13-times Ukrainian champions to cancel out Cameron Jerome's earlier effort.
Athletic Bilbao, starting their first season under eccentric former Argentina and Chile coach Marcelo Bielsa, won 2-1 at Slovan Bratislava with goals from Markel Susaeta and Iker Muniain.
Sporting scored twice in the first 20 minutes to win 2-0 at FC Zurich.
Hugo Almeida (L) of Besiktas celebrates his goal with his teammate Ekrem Dag during their Europa League Group E soccer match against Maccabi Tel Aviv at Inonu stadium in Istanbul
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