Theo Walcott's expected recovery from a knock sustained against Bolton will be a major boost for Wenger who initially thought the England flyer had suffered a serious injury.
They will definitely be without Jack Wilshere though while fellow midfielder Yossi Benayoun is unlikely to have recovered from a thigh strain.
Olympiakos head into the match in better shape than they were for their opening group match against Marseille two weeks ago when they lost 1-0 in Athens.
Ernesto Valverde's team had not played a competitive match before that game due to the fact their opening two Super League games were postponed as a result of a match-fixing scandal.
The Greek Champions have since won both of their Super League fixtures.
Valverde has minimal injury worries with the only notable absentee being Greece starlet Giannis Fetfatzidis, who is still recovering from a groin strain. Midfielders Francisco Yeste and Ljubomir Fejsa both face late fitness tests.
Probable teams:
Arsenal: 13-Wojciech Szczesny; 3-Bacary Sagna, 4-Per Mertesacker, 6-Laurent Koscielny, 28-Kieran Gibbs; 8-Mikel Arteta, 17-Alex Song, 27-Gervinho, 23-Andrei Arshavin 10-Robin van Persie, 14-Theo Walcott
Olympiakos: 17-Franco Costanzo, 35-Vassilis Torossidis, 4-Olof Mellberg, 21-Avraam Papadopoulos, 20-Jose Holebas; 3-Francois Modesto, 31-Pablo Orbaiz, 93-Djamel Abdoun, 19-David Fuster, 14-Kevin Mirallas; 10-Rafik Djebbour
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