Aaron Ramsey, a player that Wales manager Chris Coleman believes has the talent to represent any international side, will start Saturday's World Cup Group D qualifier against Serbia in Cardiff.
Midfielder Ramsey has made only four appearances this season for Arsenal and missed Wales' first three qualifiers against Moldova, Austria and Georgia because of a hamstring injury.
"There's not a team on the planet he could not play for. Take him out of any team and it's a loss," Coleman told reporters on Friday.
"We were without him for the first three games which was a blow for us, it would be a blow for anyone. It's disappointing and frustrating."
Wales have one win and two draws from their three qualifying matches and are third in the table, two points behind Serbia and Ireland.
Ramsey, 25, was instrumental in his country's surge to the semi-finals of the European Championship earlier this year and has scored a total of 11 goals in 44 internationals.
With only the group winners automatically qualifying for the 2018 World Cup in Russia, Coleman will gamble on Ramsey's lack of match fitness against Serbia.
"However long he'll last physically we don't know but we do know he's generally probably one of the fittest players playing football," the 46-year-old said.
Image: Aaron Ramsey
Photograph: Nils Petter Nilsson/Ombrello/Getty Images