Indian ace Leander Paes and his Zimbabwean partner Cara Black suffered a straight-set defeat to Anna-Lena Groenefeld and Mark Knowles and bowed out of the mixed doubles at the US Open in New York on Tuesday.
The second seeds, who won the 2010 Wimbledon mixed doubles title, lost 3-6, 4-6 to the German-Bahamian pair in the quarter-finals.
Paes and Black had clinched the Australian Open mixed doubles title in January.
India's Rohan Bopanna and his Pakistani partner Aisam-ul-Haq Qureshi are still in the reckoning in the men's doubles. They take on the South African-Belgian combo of Wesley Moodie and Dick Norman in the quarter-final.