Tayshaun Prince added 22 points and eight rebounds for the Pistons, who took advantage of Tim Duncan's ankle injury, which forced him out of the game after just two minutes.
The team said after the game x-rays were negative. Duncan missed two games earlier this month with a sprained right ankle. He was listed as day-to-day.
Rasheed Wallace added 15 points and six rebounds for the Pistons, while Carlos Arroyo chipped in 13 points in just 23 minutes off the bench for Detroit.
Devin Brown led San Antonio with 18 points while Beno Udrih added 15 points.
In Toronto, LeBron James became the youngest NBA player to score 50 or more points in a game when he scored 56 in the Cleveland Cavaliers 105-98 loss by the Raptors.
James set a franchise record with his haul, shooting 18-for-36 from the field and 14-for-15 from the line. He had six three-pointers along with 10 rebounds and five assists.
Jalen Rose led Toronto with 30 points and Donyell Marshall added 24 points.
In Indianapolis, Vince Carter scored 39 points and grabbed 11 rebounds in the New Jersey Nets' 94-85 victory over the Indiana Pacers.
Nenad Krstic added 18 points for the Nets, while Jason Kidd had 14 points, 12 rebounds and seven assists.
Stephen Jackson led Indiana with 21 points.
In Memphis, Joe Johnson scored 28 points in the Phoenix Suns' 97-91 victory over the Grizzlies.
Shawn Marion had 14 points and 16 rebounds for the Suns, who also got 13 points and 13 assists from Steve Nash.
Shane Battier's 20 points led Memphis.