Samuel Eto'o scored twice to give ambitious Anzhi Makhachkala a 2-0 Europa League win over Young Boys on Thursday while Liverpool lost 3-2 at home to Udinese and Videton, Sparta Prague and Molde pulled off surprise wins.
Defending champions Atletico Madrid, one of several teams fielding a second string line-up, needed a goal deep in stoppage time from Cristian Rodriguez to overcome defiant Czechs Viktoria Plzen 1-0.
The Uruguayan player known as 'The Onion' let fly from outside the area to leave Diego Simeone's team with six points from two games at the top of Group B.
Eto'o, who last week ended his stand-off with Cameroon officials and agreed to play for his country again, converted a 62th minute penalty against the run of play.
He then turned in Oleg Shatov's cross in the last minute to complete a 2-0 win over the Swiss side and extend Anzhi's unbeaten run to seven matches in the competition, including the qualifiers.
The Group A match was played in front of a sparse crowd in Moscow, where Anzhi are playing for security reasons after UEFA refused to let them stage matches in the violence-plagued Dagestan region.
Liverpool were another side to rest their regulars but still took a first-half lead through Jonjo Shelvey.
However, Antonio Di Natale levelled with a superbly-taken goal immediately after the break and he cleverly set a third for Giovanni Pasquale shortly after Liverpool defender Sebastian Coates headed into his own goal.
Liverpool brought on Uruguay forward Luis Suarez who scored with a perfectly flighted free kick but could not inspire an equaliser.
Videoton gave Hungarian football a rare boost with a 3-0 win over Sporting, the goals coming in the first half from Paulo Vinicius, Filipe Oliveira and Nemanja Nikolic, while Sparta Prague beat last season's runners-up Athletic Bilbao 3-1.
Molde, coached by former Manchester United forward Ole Gunnar Solskjaer beat Germany's VfB Stuttgart 2-0 with second-half goals from Jo Inge Berget and Daniel Chima.
Inter Milan enjoyed an easy 3-1 win at Azerbaijan's Neftci thanks to first-half goals from Philippe Coutinho, Joel Obi and Marko Livaja, all set up by Colombian Fredy Guarin.
Compatriots Lazio scraped a 1-0 win at home to Slovenia's Maribor with a 62nd minute goal by Brazilian Ederson. They moved top of Group J with four points.
Tottenham Hotspur are still awaiting their first win after drawing 1-1 at Panathinaikos.
Napoli, another team resting their top players with Edinson Cavani among those on the bench, were the only letdown for Italy as they were over-run at Dick Advocaat's PSV where Jeremain Lens, Dries Martins and Marcelo shared the goals.
Former England manager Steve McClaren's Twente Enschede narrowly avoided defeat at Helsingborg after Rasmus Bengtsson and Douglas scored in the last quarter of an hour to give them a 2-2 draw. Two goals from Nicola Djurdic had put the Swedes 2-0 ahead at halftime.
Olympique Marseille scored four times in the last half hour as they came from behind to demolish AEL Limassol 5-1 and fellow French side Olympique Lyon, having squandered a 3-1 lead, won 4-3 at Israeli champions Hapoel Kiryat Shmona.
Gueida Fofana rose to head the winner in stoppage time, his second goal of the game.
Photograph: Phil Noble/Reuters