Strikers Henrik Larsson and Samuel Eto'o scored in Barcelona's 2-0 win at Real Sociedad on Saturday to open a 12-point lead at the top of the Primera Liga.
Brazilian playmaker Ronaldinho helped set up the goals at the beginning of each half and Barca never really stretched themselves against a side flirting with relegation.
The pressure now switches on to the chasing pair of Valencia and Real Madrid who are level on 52 points.
Second-placed Valencia are away to Racing Santander on Sunday when third-placed Real play Real Betis in the Bernabeu.
Earlier Deportivo Coruna recovered from their midweek King's Cup semi-final defeat to Espanyol to beat Getafe 2-1away.
Depor took the lead against the run of play through midfielder Victor in 30th minute, but Getafe continued to press and striker Sergio Pachon levelled in the 58th.
Getafe were reduced to 10 men when Jaime Gavilan was sent off in the 72nd minute and substitute Xisco headed the winner for Depor a minute later.
The Galicians climbed to eighth in the table.
Later on Saturday the battle for European soccer takes centre stage when Villarreal host Atletico Madrid.