South Americans Pablo Cuevas and Luis Horna captured the men's doubles title at the French Open on Saturday after they beat second seeds Daniel Nestor and Nenad Zimonjic 6-2, 6-3.

The Uruguayan-Peruvian duo, playing together for the first time at a tour event, became the first South American pair to win a Grand Slam men's doubles title since tennis turned professional in 1968.

After knocking out top seeds Mike and Bob Bryan in the quarter-finals, they capped an incredible tournament by quelling the challenge of the second seeds on Philippe Chatrier Court on Saturday.

"Everybody dreams about playing the big tournaments and doing good, so winning a grand slam, winning the French Open for us... I don't think right now in this moment we're going to realise how huge this is," said Horna, the first Peruvian to win a major title in the professional era.

"Maybe in a couple of weeks or couple of months or couple of years, I don't know. Some day we will figure it out. But right now we are happy and surprised a little bit, also.

"Winning a grand slam in doubles is a wonderful experience, and that's something I'll remember."

The defeat ended a disappointing couple of days for Serbia's Zimonjic, who also emerged second best in the mixed doubles final.