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PowerGrid was the top laggard in the Sensex pack, shedding around 2 per cent, followed by IndusInd Bank, Reliance, L&T, UltraTech Cement and Bajaj Finance.
Benchmark indices Sensex and Nifty retreated from record high levels on Wednesday following intense selling in Reliance and HDFC twins as investors turned cautious ahead of the outcome of the US Federal Reserve's policy meeting.
The 30-share BSE index ended 271.07 points or 0.51 per cent lower at 52,501.98.
It had closed at an all-time high of 52,773.05 on Tuesday.
The broader NSE Nifty retreated from a record and declined 101.70 points or 0.64 per cent to 15,767.55.
PowerGrid was the top laggard in the Sensex pack, shedding around 2 per cent, followed by IndusInd Bank, Reliance, L&T, UltraTech Cement and Bajaj Finance.
On the other hand, Nestle, NTPC, ONGC, Bajaj Finserv Hindustan Unilever and Infosys were among the gainers.
Investors kept an eye on the two-day US Federal Reserve meeting, which is set to conclude on Wednesday.
Lack of fresh trigger from overseas markets also weighed on the local stocks as Asian markets closed mixed.
Bourses in Shanghai, Hong Kong and Tokyo ended on a negative note, while Seoul settled with gains.
Meanwhile, the rupee slips 1 paisa to close at 73.32 against the US dollar, logging its seventh straight day of losses.
Foreign institutional investors (FIIs) emerged as net buyers in the capital market as they bought shares worth Rs 633.69 crore on Tuesday, as per provisional exchange data.